31 results
Dissolution of Hectorite in Inorganic Acids
- P. Komadel, J. Madejová, M. Janek, W. P. Gates, R. J. Kirkpatrick, J. W. Stucki
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- Journal:
- Clays and Clay Minerals / Volume 44 / Issue 2 / April 1996
- Published online by Cambridge University Press:
- 28 February 2024, pp. 228-236
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The effect of acid type and concentration on the reaction rate and products of dissolution of hectorite in inorganic acids was investigated. The dissolution of hectorite in hydrochloric (HCl), nitric (HNO3) and sulphuric (H2SO4) acids was characterized using quantitative chemical analysis, infrared (IR) and multinuclear MAS NMR spectroscopies. The rate of dissolution increased with acid concentration and decreased in the order HCl ≥ HNO3 = H2SO4 at the same molar concentration. No differences were found in the reaction products of hectorite treated with the three acids. The rate of Li dissolution was slightly greater than that of Mg at lesser acid concentrations (0.25 M), indicating that protons preferentially attack Li octahedra. The gradual changes in the Si-O IR bands reflects the extent of hectorite dissolution. The analysis of 29Si MAS NMR spectra relative peak intensities with dissolution time and acid concentration provided direct dissolution rates for tetrahedral (Q3) Si. After acid dissolution, most Si was bound in a three dimensional framework site (Q4), but a substantial part also occurred in the Si(OSi)3OH (Q31OH) and Si(OSi)2(OH)2 (Q220H) environments. These three sites probably occur in a hydrous amorphous silica phase. Both AlJV and AlVt rapidly disappeared from 27Al MAS NMR spectra of the dissolution products with acid treatment. The changes in IR and MAS NMR spectra of hectorite due to acid dissolution are similar to those of montmorillonite.
27Al Mas NMR and Aluminum X-Ray Absorption Near Edge Structure Study of Imogolite and Allophanes
- Ph. Ildefonse, R. J. Kirkpatrick, B. Montez, G. Calas, A. M. Flank, P. Lagarde
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- Journal:
- Clays and Clay Minerals / Volume 42 / Issue 3 / June 1994
- Published online by Cambridge University Press:
- 28 February 2024, pp. 276-287
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This paper compares the results of 27Al nuclear magnetic resonance spectroscopy (NMR) and Al-K-edge X-ray Absorption Near Edge Structure (XANES) of natural imogolite and allophanes and some crystalline reference minerals. All soil allophanes studied contain 4-coordinated Al (AlIV). The highest relative proportion of AlIV, 21% of the total Al, was found in Si-rich allophane. This value is close to that found in spring allophanes, which were previously considered to be different from soil allophanes. For a quantitative determination of the AlIV/Altotal ratio, NMR is more reliable than XANES, because of the sensitivity of the chemical shift to low AlIV concentrations, but XANES may be used even if paramagnetic impurities (mostly Fe) are present. Al-K XANES also yields more information than NMR on the local environment of AlVI and especially site multiplicity. AlVI XANES of imogolite and allophanes are similar regardless of the Al/Si ratio. They yield two well-resolved resonances with maxima near 1568 and 1570 eV, which indicates the presence of a unique AlVI site by comparison with crystalline references. The presence of only one AlVI site indicates that imogolite and allophanes have an octahedral sheet with a structure similar to 2/1 dioctahedral phyllosilicates but different from gibbsite or kaolinite, previously considered as structural analogues. The 27AlIV MAS NMR peak maxima of allophanes are between 58.6 and 59.8 ppm, in the range observed for crystalline and amorphous framework alumino-silicates, and less positive than those of sheet silicates, which are typically in the range 65–75 ppm. 27Al-H1 CPMAS NMR spectra suggest that both AlIV and AlVI have Al-O-H linkages.
Negative symptoms in the clinic: we treat what we can describe
- Brian Kirkpatrick, Lauren Luther, Gregory P. Strauss
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- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 1 / July 2023
- Published online by Cambridge University Press:
- 10 July 2023, pp. 271-272
- Print publication:
- July 2023
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Recent research has led to important changes in the concepts and assessment of negative symptoms in schizophrenia. We review current negative symptom concepts and their clinical implications, as well as new methods of assessing these symptoms. These changes hold promise for improving our understanding and treatment of negative symptoms.
Relationship between polygenic risk scores and symptom dimensions of schizophrenia and schizotypy in multiplex families with schizophrenia
- Mohammad Ahangari, Daniel Bustamante, Robert Kirkpatrick, Tan-Hoang Nguyen, Brian C. Verrelli, Ayman Fanous, Kenneth S. Kendler, Bradley T. Webb, Silviu-Alin Bacanu, Brien P. Riley
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- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 1 / July 2023
- Published online by Cambridge University Press:
- 12 December 2022, pp. 301-308
- Print publication:
- July 2023
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Background
Psychotic disorders and schizotypal traits aggregate in the relatives of probands with schizophrenia. It is currently unclear how variability in symptom dimensions in schizophrenia probands and their relatives is associated with polygenic liability to psychiatric disorders.
AimsTo investigate whether polygenic risk scores (PRSs) can predict symptom dimensions in members of multiplex families with schizophrenia.
MethodThe largest genome-wide data-sets for schizophrenia, bipolar disorder and major depressive disorder were used to construct PRSs in 861 participants from the Irish Study of High-Density Multiplex Schizophrenia Families. Symptom dimensions were derived using the Operational Criteria Checklist for Psychotic Disorders in participants with a history of a psychotic episode, and the Structured Interview for Schizotypy in participants without a history of a psychotic episode. Mixed-effects linear regression models were used to assess the relationship between PRS and symptom dimensions across the psychosis spectrum.
ResultsSchizophrenia PRS is significantly associated with the negative/disorganised symptom dimension in participants with a history of a psychotic episode (P = 2.31 × 10−4) and negative dimension in participants without a history of a psychotic episode (P = 1.42 × 10−3). Bipolar disorder PRS is significantly associated with the manic symptom dimension in participants with a history of a psychotic episode (P = 3.70 × 10−4). No association with major depressive disorder PRS was observed.
ConclusionsPolygenic liability to schizophrenia is associated with higher negative/disorganised symptoms in participants with a history of a psychotic episode and negative symptoms in participants without a history of a psychotic episode in multiplex families with schizophrenia. These results provide genetic evidence in support of the spectrum model of schizophrenia, and support the view that negative and disorganised symptoms may have greater genetic basis than positive symptoms, making them better indices of familial liability to schizophrenia.
To Watch Before or Listen While Doing? A Randomized Pilot of Video-Modelling versus Telementored Tube Thoracostomy
- Andrew W. Kirkpatrick, Corey Tomlinson, Nigel Donley, Jessica L. McKee, Chad G. Ball, Juan P. Wachs
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- Journal:
- Prehospital and Disaster Medicine / Volume 37 / Issue 1 / February 2022
- Published online by Cambridge University Press:
- 18 February 2022, pp. 71-77
- Print publication:
- February 2022
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Background:
New care paradigms are required to enable remote life-saving interventions (RLSIs) in extreme environments such as disaster settings. Informatics may assist through just-in-time expert remote-telementoring (RTM) or video-modelling (VM). Currently, RTM relies on real-time communication that may not be reliable in some locations, especially if communications fail. Neither technique has been extensively developed however, and both may be required to be performed by inexperienced providers to save lives. A pilot comparison was thus conducted.
Methods:Procedure-naïve Search-and-Rescue Technicians (SAR-Techs) performed a tube-thoracostomy (TT) on a surgical simulator, randomly allocated to RTM or VM. The VM group watched a pre-prepared video illustrating TT immediately prior, while the RTM group were remotely guided by an expert in real-time. Standard outcomes included success, safety, and tube-security for the TT procedure.
Results:There were no differences in experience between the groups. Of the 13 SAR-Techs randomized to VM, 12/13 (92%) placed the TT successfully, safely, and secured it properly, while 100% (11/11) of the TT placed by the RTM group were successful, safe, and secure. Statistically, there was no difference (P = 1.000) between RTM or VM in safety, success, or tube security. However, with VM, one subject cut himself, one did not puncture the pleura, and one had barely adequate placement. There were no such issues in the mentored group. Total time was significantly faster using RTM (P = .02). However, if time-to-watch was discounted, VM was quicker (P = .000).
Conclusions:Random evaluation revealed both paradigms have attributes. If VM can be utilized during “travel-time,” it is quicker but without facilitating “trouble shooting.” On the other hand, RTM had no errors in TT placement and facilitated guidance and remediation by the mentor, presumably avoiding failure, increasing safety, and potentially providing psychological support. Ultimately, both techniques appear to have merit and may be complementary, justifying continued research into the human-factors of performing RLSIs in extreme environments that are likely needed in natural and man-made disasters.
Turbulence structure of neutral and negatively buoyant jets
- K. M. Talluru, S. Armfield, N. Williamson, M. P. Kirkpatrick, L. Milton-McGurk
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- Journal:
- Journal of Fluid Mechanics / Volume 909 / 25 February 2021
- Published online by Cambridge University Press:
- 29 December 2020, A14
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High-fidelity measurements of velocity and concentration are carried out in a neutral jet (NJ) and a negatively buoyant jet (NBJ) by injecting a jet of fresh water vertically downwards into ambient fresh and saline water, respectively. The Reynolds number ($Re$) based on the pipe inlet diameter ($d$) and the source velocity ($W_o$) is approximately 5900 in all the experiments, while the source Froude number based on density difference is approximately 30 in the NBJ experiments. Velocity and concentration measurements are obtained in the region $17 \leq z/d \leq 40$ ($z$ being the axial coordinate) using particle image velocimetry and planar laser induced fluorescence techniques, respectively. Consistent with the literature on jets, the centreline velocity ($W_c$) decays as $z^{-1}$ in the NJ, but in the NBJ, $W_c$ decays faster along $z$ due to the action of negative buoyancy. Nonetheless, the mean velocity ($W$) and concentration ($C$) profiles in both the flows exhibit self-similar Gaussian form, when scaled by the local centreline parameters ($W_c,C_c$) and the jet half-widths ($r^\ast _{W},r^\ast _{C}$). On the other hand, the turbulence statistics and Reynolds stress in the NBJ do not scale with $W_c$. The results of autocorrelation functions, integral length scales and two-dimensional correlation maps show the similarity of turbulence structure in the NJ and the NBJ when the axial and radial distances are normalised by the local jet half-width. Further, the spectra and probability density functions are similar on the axis and only minor differences are seen near the jet interface. The above findings are fundamentally consistent with our recent analysis (Milton-McGurk et al., J. Fluid Mech., 2020b), where we observed that the mean and turbulence statistics in the NBJ have different development characteristics. Overall, we find that the turbulence structure of the NBJ (when scaled by local velocity and length scales) is very similar to the momentum-driven NJ, and the differences (e.g. spreading rate, scaling of turbulence intensities, etc.) between the NJ and the NBJ seem to be of secondary importance.
Destratification of thermally stratified turbulent open-channel flow by surface cooling
- Michael P. Kirkpatrick, N. Williamson, S. W. Armfield, V. Zecevic
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- Journal:
- Journal of Fluid Mechanics / Volume 899 / 25 September 2020
- Published online by Cambridge University Press:
- 28 July 2020, A29
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Destratification of thermally stratified open-channel flow by surface cooling is investigated using direct numerical simulation. The initial states are the equilibrium states resulting from radiative heating. Using these states as initial conditions, a series of direct numerical simulations was run with radiative heating removed and a constant, uniform cooling flux applied at the upper surface. The flow evolves until the initial stable stratification is broken down and replaced by unstable stratification driven by surface cooling. The destratification process is described with reference to the evolution of the internal structure of the turbulent flow field. Based on these observations, we conclude that the dominant time scales in the flow from the perspective of destratification are the time scales associated with shear ${t}_{\tau }$, convection ${t}_*$ and stable density stratification ${t}_N$. Scaling arguments are then used to derive a scaling relationship for destratification rate as a function of a friction Richardson number $Ri_{\tau } = ( {t}_{\tau }/ {t}_N)^2$ and a convection Richardson number $Ri_* = ( {t}_*/ {t}_N)^2$. The relationship takes the form ${\mathcal {D}}_N = C_1Ri_{\tau }^{-1} + C_2Ri_*^{-1}$, where ${\mathcal {D}}_N$ is the destratification rate non-dimensionalised with respect to $ {t}_N$ and $C_1$ and $C_2$ are model coefficients. The relationship is compared with simulation results and is shown to accurately predict the destratification rate in the simulations across a range of parameters. This relationship is then integrated to give a formula for the time taken for the flow to destratify.
Evolution of thermally stratified turbulent open channel flow after removal of the heat source
- Michael P. Kirkpatrick, N. Williamson, S. W. Armfield, V. Zecevic
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- Journal:
- Journal of Fluid Mechanics / Volume 876 / 10 October 2019
- Published online by Cambridge University Press:
- 01 August 2019, pp. 356-412
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Evolution of thermally stratified open channel flow after removal of a volumetric heat source is investigated using direct numerical simulation. The heat source models radiative heating from above and varies with height due to progressive absorption. After removal of the heat source the initial stable stratification breaks down and the channel approaches a fully mixed isothermal state. The initial state consists of three distinct regions: a near-wall region where stratification plays only a minor role, a central region where stratification has a significant effect on flow dynamics and a near-surface region where buoyancy effects dominate. We find that a state of local energetic equilibrium observed in the central region of the channel in the initial state persists until the late stages of the destratification process. In this region local turbulence parameters such as eddy diffusivity $k_{h}$ and flux Richardson number $R_{f}$ are found to be functions only of the Prandtl number $Pr$ and a mixed parameter ${\mathcal{Q}}$, which is equal to the ratio of the local buoyancy Reynolds number $Re_{b}$ and the friction Reynolds number $Re_{\unicode[STIX]{x1D70F}}$. Close to the top and bottom boundaries turbulence is also affected by $Re_{\unicode[STIX]{x1D70F}}$ and vertical position $z$. In the initial heated equilibrium state the laminar surface layer is stabilised by the heat source, which acts as a potential energy sink. Removal of the heat source allows Kelvin–Helmholtz-like shear instabilities to form that lead to a rapid transition to turbulence and significantly enhance the mixing process. The destratifying flow is found to be governed by bulk parameters $Re_{\unicode[STIX]{x1D70F}}$, $Pr$ and the friction Richardson number $Ri_{\unicode[STIX]{x1D70F}}$. The overall destratification rate ${\mathcal{D}}$ is found to be a function of $Ri_{\unicode[STIX]{x1D70F}}$ and $Pr$.
Price Determinants of Performance-Tested Bulls over Time
- Christopher N. Boyer, Kelsey Campbell, Andrew P. Griffith, Karen L. DeLong, Justin Rhinehart, David Kirkpatrick
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- Journal:
- Journal of Agricultural and Applied Economics / Volume 51 / Issue 2 / May 2019
- Published online by Cambridge University Press:
- 25 March 2019, pp. 304-314
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We estimate the values of bull phenotypic traits, performance measurements, and expected progeny differences (EPDs) over time using bull sale data from an auction in Tennessee from 2006 to 2016. Moreover, we determine how a state partial-cost reimbursement program for bulls with certain EPDs affects bull sale price. Purebred seed stock producers in this region should focus on selling large, fast-growing, mature bulls that produce lighter calves for reduced calving stress. The state cost-share payment did not significantly increase bull prices in most years, meaning this payment was retained by cow-calf producers in most years.
Cost-utility analysis of antiviral use under pandemic influenza using a novel approach – linking pharmacology, epidemiology and heath economics
- D. B. C. Wu, N. Chaiyakunapruk, C. Pratoomsoot, K. K. C. Lee, H. Y. Chong, R. E. Nelson, P. F. Smith, C.M. Kirkpatrick, M. A. Kamal, K. Nieforth, G. Dall, S. Toovey, D. C. M. Kong, A. Kamauu, C. R. Rayner
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- Journal:
- Epidemiology & Infection / Volume 146 / Issue 4 / March 2018
- Published online by Cambridge University Press:
- 15 February 2018, pp. 496-507
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Simulation models are used widely in pharmacology, epidemiology and health economics (HEs). However, there have been no attempts to incorporate models from these disciplines into a single integrated model. Accordingly, we explored this linkage to evaluate the epidemiological and economic impact of oseltamivir dose optimisation in supporting pandemic influenza planning in the USA. An HE decision analytic model was linked to a pharmacokinetic/pharmacodynamics (PK/PD) – dynamic transmission model simulating the impact of pandemic influenza with low virulence and low transmissibility and, high virulence and high transmissibility. The cost-utility analysis was from the payer and societal perspectives, comparing oseltamivir 75 and 150 mg twice daily (BID) to no treatment over a 1-year time horizon. Model parameters were derived from published studies. Outcomes were measured as cost per quality-adjusted life year (QALY) gained. Sensitivity analyses were performed to examine the integrated model's robustness. Under both pandemic scenarios, compared to no treatment, the use of oseltamivir 75 or 150 mg BID led to a significant reduction of influenza episodes and influenza-related deaths, translating to substantial savings of QALYs. Overall drug costs were offset by the reduction of both direct and indirect costs, making these two interventions cost-saving from both perspectives. The results were sensitive to the proportion of inpatient presentation at the emergency visit and patients’ quality of life. Integrating PK/PD–EPI/HE models is achievable. Whilst further refinement of this novel linkage model to more closely mimic the reality is needed, the current study has generated useful insights to support influenza pandemic planning.
Entrainment across a sheared density interface in a cavity flow
- N. Williamson, M. P. Kirkpatrick, S. W. Armfield
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- Journal:
- Journal of Fluid Mechanics / Volume 835 / 25 January 2018
- Published online by Cambridge University Press:
- 29 November 2017, pp. 999-1021
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The entrainment of fluid across a sheared density interface has been examined experimentally in a purging cavity flow. In this flow, a long straight cavity with sloped entry and exit boundaries is located in the base of a straight open channel. Dense cavity fluid is entrained from the cavity into the turbulent overflow. The cavity geometry has been designed to ensure there is no separation of the overflow in the cavity region, with the goal of avoiding cavity-specific entrainment mechanisms as have been encountered in most previous experiments using similar arrangements. Results are obtained over a bulk Richardson number range $Ri_{b}=g\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}D/\unicode[STIX]{x1D70C}_{0}U_{b}^{2}=1$ to 19, where $D$ and $U_{b}$ are the depth of the mixed layer and bulk velocity in the cavity, respectively. The experiments cover the Reynolds number range $Re=U_{b}D/\unicode[STIX]{x1D708}=7100$ to 15 100 and interface length to mixed layer depth ratios of 2.4 to 16. Particle image velocimetry and laser induced fluorescence measurements indicate the flow regime over this entire range is one dominated by the Holmboe wave instability. The non-dimensional entrainment rate, $E=u_{e}/U_{b}$, is shown to scale with the bulk Richardson number. We find that the entrainment scaling $E=CRi_{b}^{-1.38}$ applies over the entire experimental range, with no apparent dependence on interface length. The exponent in the scaling is similar to previous non-cavity-based sheared interface flows, however, the constant $C$ is up to an order of magnitude smaller. Close agreement is, however, obtained by instead correlating entrainment with the local gradient Richardson number centred on the interface, rather than bulk quantities. We obtain $E=0.0021Ri_{g}^{-0.63}$ for data over $10<Ri_{g}<50$, where $Ri_{g}=\langle g\unicode[STIX]{x2202}\unicode[STIX]{x1D70C}/\unicode[STIX]{x1D70C}_{0}\unicode[STIX]{x2202}z\rangle /\langle (\unicode[STIX]{x2202}U/\unicode[STIX]{x2202}z)^{2}\rangle$. The density interface is much thinner and therefore more stable in the present flow configuration compared with other published results for the same bulk Richardson number. We suggest that our configuration ensures a sharp mixing layer profile at the upstream end of the cavity even at relatively low bulk Richardson numbers of $Ri_{b}=1$ and that the reduced mixing in the Holmboe wave regime allows the interface to retain its sharp character over the cavity length, resulting in weak sensitivity to cavity length.
3 - Radiation therapy for gliomas
- Edited by John H. Sampson, Duke University Medical Center, Durham
- Darell D. Bigner, Allan H. Friedman, Henry S. Friedman, Roger McLendon
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- Book:
- The Duke Glioma Handbook
- Published online:
- 05 March 2016
- Print publication:
- 31 March 2016, pp 49-75
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Transition to stably stratified states in open channel flow with radiative surface heating
- N. Williamson, S. W. Armfield, M. P. Kirkpatrick, S. E. Norris
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- Journal:
- Journal of Fluid Mechanics / Volume 766 / 10 March 2015
- Published online by Cambridge University Press:
- 09 February 2015, pp. 528-555
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Direct numerical simulations (DNS) of turbulent stratified flow in an open channel with an internal heat source following the Beer–Lambert law from the surface are used to investigate the transition from neutral to strongly stable flow. Our buoyancy bulk parameter is defined through the ratio of the domain height ${\it\delta}$ to $\mathscr{L}$ , a bulk Obukhov length scale for the flow. We cover the range ${\it\lambda}={\it\delta}/\mathscr{L}=0{-}2.0$ , from neutral conditions to the onset of the stable regime, with the Reynolds number range $Re_{{\it\tau}}=200{-}800$ , at a Prandtl number of 0.71. The result is a boundary layer flow where the effects of stratification are weak in the wall region but progressively stronger in the outer layer up to the free surface. At ${\it\lambda}\simeq 1$ the turbulent kinetic energy (TKE) budget is in local equilibrium over a region extending from the near-wall region to a free-surface affected region a distance $l_{{\it\nu}}$ from the surface, with $l_{{\it\nu}}/{\it\delta}\sim Re^{-1/2}$ . In this equilibrium region the flow can be characterised by the flux Richardson number $R_{f}$ and the local Obukhov length scale ${\it\Lambda}$ . At higher ${\it\lambda}$ local mixing limit conditions are observed over an extended region. At ${\it\lambda}=2$ the flux Richardson number approaches critical limit values of $R_{f,c}\simeq 0.18$ and gradient Richardson number $Ri_{c}\simeq 0.2$ . At high ${\it\lambda}$ , we obtain a flow field where buoyancy interacts with the smallest scales of motion and the turbulent shear stress and buoyancy flux are suppressed to molecular levels. We find that this regime can be identified in terms of the parameter $Re_{\mathscr{L},c}=\mathscr{L}u_{{\it\tau}}/{\it\nu}\lesssim 200{-}400$ (where $u_{{\it\tau}}$ is the friction velocity and ${\it\nu}$ the kinematic viscosity), which is related to the $L_{\ast }$ parameter of Flores and Riley (Boundary-Layer Meteorol., vol. 139 (2), 2011, pp. 241–259) and buoyancy Reynolds number $\mathscr{R}$ . With energetic equilibrium attained, the local buoyancy Reynolds number, $Re_{{\it\Lambda}}={\it\Lambda}\langle u^{\prime }w^{\prime }\rangle ^{1/2}/{\it\nu}$ , is directly related to the separation of the Ozmidov ( $l_{O}$ ) and Kolmogorov ( ${\it\eta}$ ) length scales in the outer boundary layer by $Re_{{\it\Lambda}}\simeq \mathscr{R}\equiv (l_{O}/{\it\eta})^{4/3}$ . The inner wall region has the behaviour $\mathscr{R}\sim Re_{\mathscr{L}}Re_{{\it\tau}}$ , in contrast to stratified boundary layer flows where the buoyancy flux is non-zero at the wall and $\mathscr{R}\sim Re_{\mathscr{L}}$ .
Contributors
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- By Venkataraman Anantharaman, Philip D. Anderson, Christopher W. Baugh, J. Stephen Bohan, Kirsten Boyd, Matthias Brachmann, Peter R. Brown, Shelley Calder, David Callaway, Peter Cameron, Jody Crane, Meaghan Cussen, Christina Dempsey, Jonathan A. Edlow, Thomas Fleischmann, Robert L. Freitas, John D. Halamka, Manuel Hernandez, Cherri Hobgood, Jock Hoffman, Steven Horng, Kirk B. Jensen, Jennifer R. Johnson, Stephanie Kayden, Tasnim Khan, Daniel G. Kirkpatrick, James Lennon, Mary Leupold, Thom Mayer, J. Lawrence Mottley, Scott B. Murray, Deirdre Mylod, Larry A. Nathanson, Michael P. Pietrzak, Elke Platz, Nadeem Qureshi, Matthew M. Rice, Andrew Schenkel, Chet Schrader, Puneet Seth, Richard B. Siegrist, David Smith, Robert E. Suter, Carrie Tibbles, Sebastian N. Walker, Lee A. Wallis, Julie Welch, Leana S. Wen
- Edited by Stephanie Kayden, Philip D. Anderson, Robert Freitas, Elke Platz
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- Book:
- Emergency Department Leadership and Management
- Published online:
- 05 December 2014
- Print publication:
- 27 November 2014, pp ix-xii
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Prandtl number dependence and instability mechanism of the near-field flow in a planar thermal plume
- Tae Hattori, S. E. Norris, M. P. Kirkpatrick, S. W. Armfield
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- Journal:
- Journal of Fluid Mechanics / Volume 732 / 10 October 2013
- Published online by Cambridge University Press:
- 30 August 2013, pp. 105-127
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This study considers the convective-type instability of the near-field flow of a planar, pure thermal plume with a finite area source. Previous studies revealed the existence of an off-axis thermal boundary-layer instability, driving a puffing instability in the central ascending column, and qualitatively showed correlations between instabilities in these two flow regions. This paper extends the analysis to examine the effect of Prandtl number on transitional near-field behaviours and reports on the stability characteristics of a near-field, pure thermal plume based on a direct stability analysis. The variations in flow behaviours in response to symmetric and asymmetric disturbances suggest the existence of coupled instability mechanisms in the off-axis thermal boundary layer and the central ascending column.
Transition to oscillatory flow in a differentially heated cavity with a conducting partition
- N. Williamson, S. W. Armfield, M. P. Kirkpatrick
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- Journal:
- Journal of Fluid Mechanics / Volume 693 / 25 February 2012
- Published online by Cambridge University Press:
- 28 November 2011, pp. 93-114
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Numerical evidence is presented for previously unreported flow behaviour in a two-dimensional rectangular side-heated cavity partitioned in the centre by vertical wall with an infinite conductivity. In this flow heat is transferred between both sides of the cavity through the conducting wall with natural convection boundary layers forming on all vertical surfaces. Simulations have been conducted over the range of Rayleigh numbers at Prandtl number and at aspect ratios of where and are the height and width of the cavity. It was found that the thermal coupling of the boundary layers on either side of the conducting partition causes the cavity flow to become absolutely unstable for a Rayleigh number at which otherwise similar non-partitioned cavity flow is steady but convectively unstable. Additionally, unlike the non-partitioned cavity, which eventually bifurcates to a multi-modal oscillatory regime, this bifurcation is manifested as a single mode oscillation with , where is the temperature difference between the hot and cold walls, is the gravitational acceleration, is the oscillation frequency and and are the fluid viscosity and coefficient of thermal expansion respectively. The critical Rayleigh number for this transition occurs between for and for , indicating that the instability has an aspect ratio dependence.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Rate of Leishmania-induced skin-lesion development in rodents depends on the site of inoculation
- C. E. Kirkpatrick, T. J. Nolan, J. P. Farrell
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- Journal:
- Parasitology / Volume 94 / Issue 3 / June 1987
- Published online by Cambridge University Press:
- 06 April 2009, pp. 451-465
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Regional differences in the response of mice to infection with three strains of dermotropic Leishmania spp. were shown for skin covering the trunk. Lesions tended to appear earlier and to grow more rapidly on sites over the caudal half of the body than the cranial half, and caudal lesions were more likely than cranial ones to result in metastatic disease in susceptible strains of mice. Site-related variations in lesion development were observed in different strains of mice as well as in golden hamsters. The effect of these regional differences on the development of some parasite-specific, immunological reactions was examined, as were parasite thermosensitivity and location-related variations in host skin temperature as possible explanations.
COMMISSION 45: STELLAR CLASSIFICATION
- Christopher J. Corbally, Sunetra Giridhar, Thomas H. Lloyd Evans, Coryn A. L. Bailer-Jones, Roberta M. Humphreys, Joseph D. Kirkpatrick, Xavier Luri, Dante Minniti, Laura E. Pasinetti, Vytautas P. Straižys, Werner W. Weiss
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- Journal:
- Proceedings of the International Astronomical Union / Volume 3 / Issue T26B / December 2007
- Published online by Cambridge University Press:
- 18 November 2008, pp. 162-163
- Print publication:
- December 2007
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The Business Meeting of Commission 45 was held on 16 August 2006. It was attended by the president and vice-president of the Commission as well as by twenty other members of the Commission. Attendance was limited, as usual, by the unavoidable occurrence of parallel sessions.
Ultracool Neighbors from 2MASS
- Kelle L. Cruz, I. Neill Reid, P. J. Lowrance, J. Davy Kirkpatrick, J. Liebert, N. Gorlova, C. Cooper
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- Journal:
- Symposium - International Astronomical Union / Volume 211 / 2003
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- 26 May 2016, pp. 201-202
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- 2003
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We present initial results of an all-sky search for cool, low-mass stars and brown dwarfs within 20 pc. We have used the near-infrared photometry provided by the 2-Micron All Sky Survey (2MASS) Second Incremental Data Release to create a target list of 1793 candidates with 6 < J < 17 and J – K > 1. Follow-up observations and existing data have enabled over 85% of the sample to be classified. Spectral types and distances have been derived for over 250 nearby dwarfs, including 39 newly discovered L dwarfs. In this poster, we discuss our selection methods and present preliminary results.